The AP-1 transcriptional complex: Local switch or remote command?
نویسندگان
چکیده
منابع مشابه
Modulation of the composition of AP-1 complex and its impact on transcriptional activity.
AP-1 transcription factor known to play a role in cell proliferation and neuronal activation, it is also involved in apoptosis of cells in response to stress, DNA damaging agents or lack of survival signals. AP-1 DNA binding complex is not a single transcription factor but a dimer consisting of members of Fos and Jun families. In this review, we discuss evidence that composition of the AP-1 com...
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Nuclear receptors regulate gene expression by direct activation of target genes and inhibition of AP-1. Here we report that, unexpectedly, activation by nuclear receptors requires the actions of CREB-binding protein (CBP) and that inhibition of AP-1 activity is the apparent result of competition for limiting amounts of CBP/p300 in cells. Utilizing distinct domains, CBP directly interacts with t...
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Activator protein 1 (AP-1) is a dimeric transcription factor with important roles in specifying genetic and cellular programs. AP-1 refers to a collection of DNAbinding homoand heterodimers formed by members of the JUN (c-Jun, JunB, and JunD) and FOS (c-Fos, FosB, Fra-1, and Fra-2) families, as well as ATF and MAF proteins. AP-1 dimers recognize similar and specific sequence elements in the pro...
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Steroid production in the adrenal zona glomerulosa is under the control of angiotensin II (Ang II), which, upon binding to its receptor, activates protein kinase C (PKC) within these cells. PKC is a potent inhibitor of the steroidogenic enzyme CYP17. We have demonstrated that, in the ovary, PKC activates expression of FOS, a member of the AP-1 family, and increased expression of this gene is li...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
سال: 2019
ISSN: 0304-419X
DOI: 10.1016/j.bbcan.2019.04.003